Mia Philipson
Immunotherapies to improve tissue function in cardiovascular diseases
My research group focuses on understanding what immune cells do to limit tissue damage caused by different diseases, and then developing immunotherapies that can speed up healing and improve tissue function. We have previously found that certain neutrophils, the most abundant immune cell in the blood, are crucial for the formation of new blood vessels immediately after injury, and that macrophages, which are present in all tissues of the body, take over the functions of other cells in the injured tissue, which is required for blood flow to be re-established. We now want to identify the contribution of macrophages to tissue recovery in different models of cardiovascular disease, in order to develop effective immunotherapies that may provide new treatment options for these patients.
References;
Macrophages support healing of ischemic injury by initiating transdifferentiation towards mural cells and adopting functions important for vascular support.
C Amoedo-Leite, K Parv, C Testini, C Herrera-Hidalgo, F Xu, A Giraud, M Malaquias, E Fasterius, D Holl, C Seignez, C Göritz, G Christoffersson, M Phillipson.
Nature Cardiovascular Research 3 , 685-700, 2024.
Engineered bacteria to speed up wound healing: an adaptive, randomized, double-blind, placebo-controlled, first-in-human phase 1 trial.
E Öhnstedt, E Vågesjö, A Fasth, HL Tomenius, P Dahg, S Jönsson, N Tyagi, M Åström, Z Myktybekova, L Ringstad, M Jorvid, P Frank, P Hedén, S Roos, M Phillipson.
eClinicalMedicine, 60 , 102014, 2023.
Perivascular macrophages regulate blood flow following tissue damage.
E Vågesjö*, K Parv*, D Ahl*, C Seignez, C Herrera Hidalgo, A Giraud, C Leite, O Korsgren, H Wallén, HH Hakovirta, H Rundqvist, M Essand, L Holm, RS Johnson, C Thålin, P Korpisalo, G Christoffersson, M Phillipson.
Circulation Research. 128 , 1694-1707, 2021.
This paper was highlighted in Nature Reviews Cardiology, 18 , 460, 2021.
Circulating markers of neutrophil extracellular traps are of prognostic value in COVID-19 patients.
H Ng, S Havervall, K Aguilera, K Parv, FA von Meijenfeldt, T Lisman, N Mackman, C Thålin†, M Phillipson†.
Arterioscler Thromb Vasc Biol, 41 :ATVBAHA120315267, 2020.
Editorial accompanying this article: Neutrophil Extracellular Traps as Prognostic Markers in COVID-19. A Welcome Piece to the Puzzle. AS Ondracek and IM Lang. Arterioscler Thromb Vasc Biol, 41 , 995, 2021
Accelerated skin wound healing by on-site production and delivery of CXCL12 by lactic acid bacteria.
E Vågesjö, E Öhnstedt, A Mortier, H Lofton, F Huss, P Proost, S Roos, M Phillipson.
Proc Natl Acad Sci U.S.A. 115 : 1895-1900, 2018.
A summary of this paper is published as In Translation in Cell Host & Microbe, 23:432-434, 2018.